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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HGS All Species: 26.67
Human Site: S349 Identified Species: 53.33
UniProt: O14964 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14964 NP_004703.1 777 86192 S349 A R K S P T P S A P V P L T E
Chimpanzee Pan troglodytes XP_511742 777 85768 S349 A R K S P T P S A P V P L T E
Rhesus Macaque Macaca mulatta XP_001111673 777 86015 S349 A R K S P T P S A P V P L T E
Dog Lupus familis XP_540486 782 86005 S353 A R K S P T P S A P A P L T E
Cat Felis silvestris
Mouse Mus musculus Q99LI8 775 85996 S349 A R K S P T P S A P V P L T E
Rat Rattus norvegicus Q9JJ50 776 86228 S349 A R K S P T P S A P V P L T E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001083588 751 84100 S349 V R K S P T P S A P V P I S E
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q960X8 760 85396 P347 E S S S M A S P S A P S P M P
Honey Bee Apis mellifera XP_393989 830 92147 D348 E E H S S R A D V T S P S A P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783582 784 87687 E346 Y S Q S K T F E A Q N G A A E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40343 622 70927 R251 R H K R K K D R D Y S T P E D
Red Bread Mold Neurospora crassa Q7RZJ2 724 79729 E346 R H A A A L K E Q T S N V G S
Conservation
Percent
Protein Identity: 100 95.5 98.8 92.3 N.A. 93.3 93.4 N.A. N.A. N.A. 80 N.A. N.A. 41.7 47.7 N.A. 49.4
Protein Similarity: 100 96.6 98.9 94.2 N.A. 95.6 95.6 N.A. N.A. N.A. 87.5 N.A. N.A. 55.7 60.9 N.A. 61.3
P-Site Identity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. N.A. 80 N.A. N.A. 6.6 13.3 N.A. 26.6
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. N.A. 93.3 N.A. N.A. 13.3 13.3 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.2 24.9
Protein Similarity: N.A. N.A. N.A. N.A. 40.6 41
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 0
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 50 0 9 9 9 9 9 0 67 9 9 0 9 17 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 9 9 0 0 0 0 0 9 % D
% Glu: 17 9 0 0 0 0 0 17 0 0 0 0 0 9 67 % E
% Phe: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 9 0 9 0 % G
% His: 0 17 9 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % I
% Lys: 0 0 67 0 17 9 9 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 9 0 0 0 0 0 0 50 0 0 % L
% Met: 0 0 0 0 9 0 0 0 0 0 0 0 0 9 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % N
% Pro: 0 0 0 0 59 0 59 9 0 59 9 67 17 0 17 % P
% Gln: 0 0 9 0 0 0 0 0 9 9 0 0 0 0 0 % Q
% Arg: 17 59 0 9 0 9 0 9 0 0 0 0 0 0 0 % R
% Ser: 0 17 9 84 9 0 9 59 9 0 25 9 9 9 9 % S
% Thr: 0 0 0 0 0 67 0 0 0 17 0 9 0 50 0 % T
% Val: 9 0 0 0 0 0 0 0 9 0 50 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _